Chiral molecules are building blocks of life. We develop new chiroptical technologies for detection and separation of chiral molecules in pharmaceuticals and space life detection. Specifically, we are exploiting moire chiral metasurfaces and metamaterials to improve enantiodiscrimination and enantioselective separation of molecules. Besides their strongly enhanced optical fields and forces, these metasurfaces and metamaterials can be fabricated at large scale, high throughput and low cost. We also develop reconfigurable (or responsive) chiroptical materials and devices.