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Measuring Molecular Chirality with Light

Many of the basic molecular building blocks of life are chiral species, which cannot be superimposed onto their mirror images. Efficient analysis, purification and asymmetric synthesis of chiral molecules are critical for disease diagnostics, pharmaceuticals, and space life detection. We develop nanomaterial-enhanced chiroptical measurement and manipulation for label-free enantiodiscrimination and enantioselective separation of chiral molecules. With its high sensitivity, low sample consumption, fast response, easy operation, and compactness, our chiroptical spectroscopy is being implemented for in situ space life detection and point-of-care testing of chiral biomarkers of diseases and complications.