Optical tweezers, Arthur Ashkin's Nobel Prize-winning invention, revolutionized biological system studies. Building on this, we have developed advanced optical manipulation techniques that use light to control interactions, transformations, and movements at micro- and nanoscales. Combining direct physical manipulation with light-induced thermal and chemical effects, our innovations enhance versatility, enable broader material manipulation, and operate with lower power in user-friendly setups. These breakthroughs advance precision measurement, nanomanufacturing, active matter, and micro/nanorobotics, with wide-ranging applications in life sciences, quantum technologies, healthcare, energy, and sustainability.