Metamaterial is engineered material with exotic properties not found in nature. We explore directed synthesis and assembly of metamaterials for various applications. We have invented a class of optothermal tools for the versatile fabrication of colloidal metamaterials. Roll-to-roll manufacturing is being developed to enable the large-scale implementation of moire metamaterials. Inline multiscale metrology is applied to measure structures, dynamics and properties of metamaterials. We further couple metamaterials with functional molecules, quantum dots and atomic-thin materials for quantum optics and function-enhanced devices.